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Acetic Acid → N2 [(1,1-Dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine, ethyl ester

HRID 231946
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 231946
N#N.[CH3:3][C:4]([CH3:29])([O:6][C:7]([NH:9][C@H:10]([C:26]([OH:28])=[O:27])[CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])=[O:8])[CH3:5].[N+:30](=C)=[N-:31].[C:33](O)(=O)[CH3:34].N#N.CC(C)(OC(N[C@H](C(OC)=O)CCCCNC(OCC1C=CC=CC=1)=O)=O)C>C(OCC)(=O)C.CC(C)=O.CCCCCC>[N:30]#[N:31].[CH3:5][C:4]([CH3:29])([O:6][C:7]([NH:9][C@H:10]([C:26]([O:28][CH2:33][CH3:34])=[O:27])[CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]([O:18][CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:17])=[O:8])[CH3:3]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

8

Edukt 4

HCID 176Acetic AcidHCID 9550DiazomethaneHCID 86742311N2 [(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysineHCID 131714291N2 [(1,1-Dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine, methyl ester

Produkt 1

HCID 131716012N2 [(1,1-Dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine, ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 180AcetoneLösungsmittelHCID 8058HexaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

N2 -[(1,1-Dimethylethoxy)carbonyl]-N6 -[(phenylmethoxy)carbonyl]-L-lysine (5.48 g., 14.4 mmole) is dissolved in ethyl acetate (130 ml.). Diazomethane is added until a yellow color persists. Acetic acid is added to quench the excess diazomethane, and the volatiles are evaporated. The residue is partitioned between ethyl acetate and saturated sodium bicarbonate, the organic layer is dried over sodium sulfate, filtered, and then the volatiles are evaporated. Purification of the residue by column chromatography on LPS-1 silica eluting with 30% ethyl acetate/hexane yields 4.0 g. of N2 -[(1,1-dimethylethoxy)carbonyl]-N6 -[(phenylmethoxy)carbonyl]-L-lysine, methyl ester. TLC (silica gel; hexane:acetone, 1:1) Rf =0.69.

Aufarbeitung

  1. customto quench the excess diazomethane
  2. customthe volatiles are evaporated
  3. customThe residue is partitioned between ethyl acetate and saturated sodium bicarbonate
  4. dry with materialthe organic layer is dried over sodium sulfate
  5. filtrationfiltered
  6. customthe volatiles are evaporated
  7. customPurification of the residue by column chromatography on LPS-1 silica eluting with 30% ethyl acetate/hexane
  8. customyields 4.0 g

Quellen und Nachweise

ORD-Eintrag
ord-21245ab6dfb242aea21b6a51d4edb4cb
Quelldatensatz
uspto-grants-1989_07
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04849414

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