Ethanol → HCID 15616850, Verbindung

HRID 232010

Reaktionsgleichung

Reaktionsgleichung von HRID 232010
[OH-].[Na+].[NH2:3][C@H:4]([C:8]([OH:10])=[O:9])[CH2:5][CH2:6][CH3:7].Br[CH2:12][CH3:13].S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>O>[CH2:8]([N:3]([CH2:19][CH2:20][CH2:12][CH3:13])[C@H:4]([C:8]([OH:10])=[O:9])[CH2:5][CH2:6][CH3:7])[CH2:4][CH2:5][CH3:6]

Komponenten

7

Edukt 5

HCID 702EthanolHCID 1118Sulfuric AcidHCID 6332Ethyl BromideHCID 14798Sodium Hydroxide2×HCID 65098L-Norvaline

Produkt 1

HCID 15616850HCID 15616850, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

In a mixture of 100 ml of ethanol and 40 ml of water were dissolved 8.0 g (200 mmol) of sodium hydroxide and 11.72 g (100 mmol) of L-norvaline. To the solution was added 27.41 g of 1-bromoethane, and the mixture was heated up to 70° C., followed by vigorously stirring for 5 hours. Thereafter, 4.0 g of sodium hydroxide was added thereto, and the stirring was continued for an additional time of 5 hours under the same condition. After the reaction, the reaction mixture was cooled, adjusted to a pH of 7 with sulfuric acid, and diluted with 1.5 liter of water to obtain N,N-di-n-butyl-L-norvaline as a fatty and oily product.

Aufarbeitung

  1. customwas continued for an additional time of 5 hours under the same condition
  2. customAfter the reaction
  3. temperaturethe reaction mixture was cooled

Quellen und Nachweise

ORD-Eintrag
ord-a38eab4ebf944e2b9175b0e5fc1eb758
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04851382

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