2,3-Dihydroxybutanedioic Acid → HCID 178424608, Verbindung

HRID 232022Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 232022
[N:1]1([CH2:7][C:8]2[CH:9]=[N:10][N:11]([O:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CS[C:20]1[NH:21][CH:22]=[C:23]([CH2:27][C:28]2[CH:29]=[CH:30][C:31]([CH3:34])=[N:32][CH:33]=2)[C:24](=[O:26])[N:25]=1.C(O)(=O)C(C(C(O)=O)O)O>N1C=CC=CC=1.C(O)(C)C>[N:1]1([CH2:7][C:8]2[CH:9]=[N:10][N:11]([O:13][CH2:14][CH2:15][CH2:16][NH:17][C:20]3[NH:21][CH:22]=[C:23]([CH2:27][C:28]4[CH:29]=[CH:30][C:31]([CH3:34])=[N:32][CH:33]=4)[C:24](=[O:26])[N:25]=3)[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

6

Edukt 3

HCID 8752,3-Dihydroxybutanedioic AcidHCID 138232143-(4-Piperidinomethylpyrazol-1-yloxy)propylamineHCID 178503537HCID 178503537, Verbindung

Produkt 1

HCID 178424608HCID 178424608, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

3.5 g of 3-(4-piperidinomethylpyrazol-1-yloxy)propylamine and 3.6 g of 2-methylthio-5-(2-methylpyrid-5-ylmethyl)-1H-pyrimid-4-one in 30 ml of pyridine are refluxed for 30 hours. The pyridine is distilled off and the residue is then chromatographed over neutral Al2O3 (activity level III) using methylene chloride/3% strength methanol as the mobile phase. The oil obtained is reacted with tartaric acid in isopropanol to give an amorphous solid.

Aufarbeitung

  1. distillationThe pyridine is distilled off
  2. customthe residue is then chromatographed over neutral Al2O3 (activity level III)
  3. customThe oil obtained
  4. customto give an amorphous solid

Quellen und Nachweise

ORD-Eintrag
ord-e8522393088a431c8f6a3da6b41f6ee4
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04851410

Notizen zur Reaktion

Wird geladen…