2-[(3-NITRO-2-PYRIDINYL)AMINO]ETHANOL → 2-[(3-Aminopyridin-2-yl)amino]ethan-1-ol

HRID 232032Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 232032
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[CH:7][N:6]=1>C(O)C.[Pd]>[OH:1][CH2:2][CH2:3][NH:4][C:5]1[C:10]([NH2:11])=[CH:9][CH:8]=[CH:7][N:6]=1

Komponenten

4

Edukt 1

HCID 50584182-[(3-NITRO-2-PYRIDINYL)AMINO]ETHANOL

Produkt 1

HCID 157187622-[(3-Aminopyridin-2-yl)amino]ethan-1-olAusbeute 56,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

2-(2-Hydroxyethylamino)-3-nitropyridine (8.9 g) was dissolved in ethanol (200 ml) and hydrogenated over 5% palladium on charcoal (400 mg) at 50 p.s.i. (3.45 bar) for 21/2 hours. The reaction mixture was filtered and the ethanol removed under reduced pressure, yielding the title compound (4.2 g, 56%) as a dark oil which was used without purification in 1(b) below.

Aufarbeitung

  1. custom2 hours
  2. filtrationThe reaction mixture was filtered
  3. customthe ethanol removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-49ce46402d664f128ab62857e200e773
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04851412

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