Tetrahydrofuran → HCID 20031369, Verbindung

HRID 232258Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 232258
O1CCCC1.[CH2:6]([N:11]1[CH2:16][CH2:15][N:14]([C:17]([CH:19]2[CH2:21][CH:20]2[C:22](O)=[O:23])=O)[CH2:13][CH2:12]1)[CH2:7][CH2:8][CH2:9][CH3:10].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O>[CH2:6]([N:11]1[CH2:12][CH2:13][N:14]([CH2:17][CH:19]2[CH2:21][CH:20]2[CH2:22][OH:23])[CH2:15][CH2:16]1)[CH2:7][CH2:8][CH2:9][CH3:10]

Komponenten

6

Edukt 4

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 20031396HCID 20031396, VerbindungHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 20031369HCID 20031369, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

To 100 mL of tetrahydrofuran is added 24.0 g (0.1 mol) of 2-[(4-pentylpiperazin-1-yl)carbonyl]cyclopropanecarboxylic acid and 13.6 g (0.4 mol) of lithium aluminum hydride. Reflux the reaction and monitor by thin-layer chromatography. Upon completion add 14 mL of H2O, 14 mL of 15% aqueous NaOH, and 42 mL of H2O. Remove the precipitate by suction filtration through celite and remove the solvent in vacuo to obtain the title compound.

Aufarbeitung

  1. temperatureReflux
  2. customthe reaction and monitor by thin-layer chromatography
  3. customRemove the precipitate
  4. filtrationby suction filtration through celite
  5. customremove the solvent in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-de1f78178e17401c8a8424ca6e05eeea
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04851526

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