Hydrochloric Acid → HCID 20031401, Verbindung

HRID 232288Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 232288
[C-:1]#[N:2].[Na+].CS(O[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[N:15]([CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=O)=O.Cl>CCOCC>[C:17]1([CH2:16][N:15]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]2[C:1]#[N:2])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 8929Sodium CyanideHCID 54076726HCID 54076726, Verbindung

Produkt 1

HCID 20031401HCID 20031401, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To 100 mL of ether is added 10 g (0.2 mol) of sodium cyanide and 37.3 g (0.1 mol) of 2-[bis(phenylmethyl)amino]-cyclohexanol methanesulfonate. Reflux the reaction and monitor by thin-layer chromatography. Upon completion add 1N HCl until gas evolution ceases. Remove the solvent in vacuo and add saturated aqueous sodium bicarbonate and 100 mL methylene chloride. Dry the organic phase over Na2SO4. Filter off the drying agent and evaporate the solvent in vacuo to obtain the title compound.

Aufarbeitung

  1. temperatureReflux
  2. customthe reaction and monitor by thin-layer chromatography
  3. customRemove the solvent in vacuo
  4. additionadd saturated aqueous sodium bicarbonate and 100 mL methylene chloride
  5. dry with materialDry the organic phase over Na2SO4
  6. filtrationFilter off the drying agent
  7. customevaporate the solvent in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d0921dfb842043d7a1000c1c1daa5375
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04851526

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