N-[2-(4-Methylphenoxy)ethyl]acetamide → N-Ethyl-2-(4-methylphenoxy)ethanamine

HRID 232312

Reaktionsgleichung

Reaktionsgleichung von HRID 232312
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C:8]1[CH:20]=[CH:19][C:11]([O:12][CH2:13][CH2:14][NH:15][C:16](=O)[CH3:17])=[CH:10][CH:9]=1>CCOCC>[CH2:16]([NH:15][CH2:14][CH2:13][O:12][C:11]1[CH:10]=[CH:9][C:8]([CH3:7])=[CH:20][CH:19]=1)[CH3:17]

Komponenten

4

Edukt 2

HCID 538338N-[2-(4-Methylphenoxy)ethyl]acetamideHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 20031351N-Ethyl-2-(4-methylphenoxy)ethanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a chilled suspension of 0.49 g (013 mol) lithium aluminium hydride in 50 mL anhydrous ether, add 5.0 g (025 mol) N-[2-(4-methylphenoxy)ethyl]acetamide at a rate which maintains the reaction temperature below 10° C. Allow to warm to room temperature and stir at ambient temp. for 24 hrs. After this time, quench the mixture with H2O and filter the salts. Concentrate the filtrate to obtain the title compound.

Aufarbeitung

  1. customthe reaction temperature below 10° C
  2. customAfter this time, quench the mixture with H2O
  3. filtrationfilter the salts
  4. concentrationConcentrate the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-936c3c50aef24950848ed4c0bb4bc33b
Quelldatensatz
uspto-grants-1989_07
Patentnummer
US04851526

Verknüpfte Notizen

Wird geladen…