Acetic Anhydride → 2-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

Reaktionsgleichung

[O:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[N:4][NH:3]1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([N:3]1[C:2](=[O:1])[NH:7][C:6](=[O:8])[CH:5]=[N:4]1)(=[O:11])[CH3:10]

Komponenten

Edukt 2

HCID 7918Acetic Anhydride

HCID 680371,2,4-Triazine-3,5(2H,4H)-dione

Produkt 1

HCID 212565952-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

Reaktionsbedingungen

Temperatur: 0 °C

Versuchsvorschrift

3,5-dioxo-(2H,4H)-1,2,4-triazine (48.88 g) is heated under reflux of acetic anhydride (300 ml) for 90 minutes. After cooling and concentration to dryness under vacuum, the residue is taken up in toluene (300 ml) and cooled at 0° C. for 2 hours. The white precipitate which forms is filtered off, centrifuged, and dried under vacuum at 70° C. so as to give the compound 11a (57.6 g).

Aufarbeitung

temperatureAfter cooling
concentrationconcentration to dryness under vacuum
filtrationThe white precipitate which forms is filtered off
customcentrifuged, and dried under vacuum at 70° C. so as

Quellen und Nachweise

ORD-Eintrag: ord-f7c15039966a406e986f2d3e26834dd6
Quelldatensatz: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05591743

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