Perchloric Acid → Allopregnanolone

HRID 232797

Reaktionsgleichung

Reaktionsgleichung von HRID 232797
C([O:4][C@@H:5]1[CH2:24][CH2:23][C@@:22]2([CH3:25])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:21]2[CH2:20][CH2:19][C@@:18]2([CH3:26])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:17])[CH3:16])[CH2:6]1)(=O)C.Cl(O)(=O)(=O)=O>CO>[OH:4][C@@H:5]1[CH2:24][CH2:23][C@@:22]2([CH3:25])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:21]2[CH2:20][CH2:19][C@@:18]2([CH3:26])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:17])[CH3:16])[CH2:6]1

Komponenten

4

Edukt 2

HCID 24247Perchloric AcidHCID 53835422Allopregnan-3alpha-ol-20-one acetate

Produkt 1

HCID 92786AllopregnanoloneAusbeute 107,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

3α-acetoxy-5α-pregnan-20-one (4.8 g) in 150 mL of methanol was cooled to 0° C. with an ice bath and 15.0 mL of perchloric acid was added dropwise. After 30 m of stirring, the ice bath was removed and the reaction mixture was left stirring for three days. The reaction mixture was poured into water and extracted with chloroform three times. The chloroform extracts were combined, dried over magnesium sulfate, and the solvent evaporated to give 4.57 g of crude product.

Aufarbeitung

  1. customthe ice bath was removed
  2. waitthe reaction mixture was left
  3. stirringstirring for three days
  4. additionThe reaction mixture was poured into water
  5. extractionextracted with chloroform three times
  6. dry with materialdried over magnesium sulfate
  7. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-d869891b434249c19eacca768a8e4da3
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05591733

Verknüpfte Notizen

Wird geladen…