HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → (R*,S*)-6-[5-(3-Chlorophenyl)-2-oxo-3-oxazolidinyl]-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-2,2-dicarboxylic acid diethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | Propanedioic acid, 2,2-dibromo-, 1,3-diethyl ester | HCID 69427 | — |
| Edukt | 5-(3-Chlorophenyl)-3-(1,2,3,4-tetrahydro-6,7-dihydroxynaphthalen-2-yl)-2-oxazolidinone | HCID 23358138 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Produkt | (R*,S*)-6-[5-(3-Chlorophenyl)-2-oxo-3-oxazolidinyl]-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-2,2-dicarboxylic acid diethyl ester | HCID 67619602 | 54,9% |
Reaktionsschritte
A mixture of 0.90 g of the above catechol derivative, 0.836 g of diethyl dibromomalonate and 1.8 g of powdered anhydrous potassium carbonate in 15 ml of acetone is stirred at room temperature for 18 hours. The reaction mixture is filtered and concentrated in vacuo to give 0.708 g of a mixture of diastereomers as a colorless oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05594027 |
| Quelldatensatz | uspto-grants-1997_01 |
| ORD ID | ord-fc06d8aa44f343808aff8578f99d8340 |
| Quellennotiz | uspto-grants-1997_01 |