HRID233817

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID69427

Propanedioic acid, dibromo-, diethyl ester

C7H10Br2O4

结构：O=C1OC(c2cccc(Cl)c2)CN1C1CCc2cc(O)c(O)cc2C1

HCID23358138

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C1(C(=O)OCC)Oc2cc3c(cc2O1)C[C@H](N1C[C@H](c2cccc(Cl)c2)OC1=O)CC3

HCID67619602

未命名化合物

收率 54.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A mixture of 0.90 g of the above catechol derivative, 0.836 g of diethyl dibromomalonate and 1.8 g of powdered anhydrous potassium carbonate in 15 ml of acetone is stirred at room temperature for 18 hours. The reaction mixture is filtered and concentrated in vacuo to give 0.708 g of a mixture of diastereomers as a colorless oil.

WORKUP

后处理

filtrationThe reaction mixture is filtered
concentrationconcentrated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fc06d8aa44f343808aff8578f99d8340
来源数据集: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05594027
来源说明: uspto-grants-1997_01

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[O:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:23][CH2:22][C:21]4[C:16](=[CH:17][C:18]([OH:25])=[C:19]([OH:24])[CH:20]=4)[CH2:15]3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Br[C:27](Br)([C:33]([O:35][CH2:36][CH3:37])=[O:34])[C:28]([O:30][CH2:31][CH3:32])=[O:29].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:36]([O:35][C:33]([C:27]1([C:28]([O:30][CH2:31][CH3:32])=[O:29])[O:24][C:19]2[CH:20]=[C:21]3[C:16](=[CH:17][C:18]=2[O:25]1)[CH2:15][C@H:14]([N:10]1[CH2:9][C@H:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[O:12][C:11]1=[O:13])[CH2:23][CH2:22]3)=[O:34])[CH3:37]