Sodium Hydroxide → 3-(2-Bromophenyl)propionic acid

HRID 234076

Reaktionsgleichung

Reaktionsgleichung von HRID 234076
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]([O:12]C)=[O:11].[OH-].[Na+]>C(O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]([OH:12])=[O:11]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 15712815Methyl 3-(2-bromophenyl)propanoate

Produkt 1

HCID 3160103-(2-Bromophenyl)propionic acidAusbeute 96,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of methyl 3-(2-bromophenyl)propionate (35.77 g) in ethanol (80.7 ml) was added at room temperature dropwise a solution of sodium hydroxide (11.77 g) in water (40 ml). After the reaction mixture was stirred under reflux for 2.5 hrs. and left standing for cooling, methanol was removed by distillation under reduced pressure, the residue was poured into ice-hydrochloric acid and stirred for 20 minutes. Crystalline precipitates were filtered, washed well with water, dried under reduced pressure to give the title compound (32.4 g).

Aufarbeitung

  1. temperatureunder reflux for 2.5 hrs
  2. waitand left standing
  3. temperaturefor cooling
  4. custommethanol was removed by distillation under reduced pressure
  5. additionthe residue was poured into ice-hydrochloric acid
  6. stirringstirred for 20 minutes
  7. customCrystalline precipitates
  8. filtrationwere filtered
  9. washwashed well with water
  10. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-aa64c040a29d4ca19be381a75352ec36
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05594081

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