Formic Acid → N-(4-hydroxy-2,3,6-trimethylphenyl)formamide

HRID 234267Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 234267
[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([CH3:10])[C:3]=1[CH3:11].[CH:12](O)=[O:13]>>[CH:12]([NH:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([CH3:10])[C:3]=1[CH3:11])=[O:13]

Komponenten

3

Edukt 2

HCID 284Formic AcidHCID 111055374-Amino-2,3,5-trimethylphenol

Produkt 1

HCID 21961295N-(4-hydroxy-2,3,6-trimethylphenyl)formamideAusbeute 72,5 %

Versuchsvorschrift

4-Amino-2,3,5-trimethylphenol (100 g, 662 mmol) was dissolved in formic acid (500 ml). The mixture was heated under reflux for 36 hours. The reaction mixture was poured into ice-cold water. The precipitated crystals were filtered, washed with water and dried. The crude crystals obtained were recrystallized from ethanol to obtain the desired compound (85.9 g, yield: 72.5%), m.p. 219°-220° C.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 36 hours
  3. additionThe reaction mixture was poured into ice-cold water
  4. filtrationThe precipitated crystals were filtered
  5. washwashed with water
  6. customdried
  7. customThe crude crystals obtained
  8. customwere recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-113cd4d0a87a464e9ef309e8080f4b39
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05594154

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