Potassium Carbonate → 5-Isopropyl-2-nitroaniline

HRID 23482Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 23482
FC(F)(F)C([NH:5][C:6]1[CH:11]=[C:10]([CH:12]([CH3:14])[CH3:13])[CH:9]=[CH:8][C:7]=1[N+:15]([O-:17])=[O:16])=O.C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH:12]([C:10]1[CH:9]=[CH:8][C:7]([N+:15]([O-:17])=[O:16])=[C:6]([NH2:5])[CH:11]=1)([CH3:14])[CH3:13]

Komponenten

5

Edukt 2

HCID 11430Potassium CarbonateHCID 225730622,2,2-Trifluoro-N-(5-isopropyl-2-nitro-phenyl)-acetamide

Produkt 1

HCID 225728525-Isopropyl-2-nitroaniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

2,2,2-Trifluoro-N-(5-isopropyl-2-nitro-phenyl)-acetamide (prepared in Example OO-1; 9.4 g, 34 mmol) was dissolved in MeOH (30 mL) and treated with 7% aqueous potassium carbonate solution. The reaction mixture was stirred overnight at room temperature. The reaction was diluted with water (30 mL) and extracted with EtOAc (3×50 mL). The organic layer was washed with saturated NaHCO3 solution and brine, dried (MgSO4), and concentrated. The crude product was used further without any purification. MS(APCI): 181 (M+H).

Aufarbeitung

  1. extractionextracted with EtOAc (3×50 mL)
  2. washThe organic layer was washed with saturated NaHCO3 solution and brine
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated
  5. customThe crude product was used further without any purification

Quellen und Nachweise

ORD-Eintrag
ord-64d099cf953c4a8ab3c91a3a714be01e
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06852711B2

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