Sodium borohydride → HCID 10756510, Verbindung

HRID 235199Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 235199
[C:1]1([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:12][CH:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+]>CO>[OH:9][CH:8]([C:10]1[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:14][CH:15]=1)[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 10709050HCID 10709050, Verbindung

Produkt 1

HCID 10756510HCID 10756510, VerbindungAusbeute 100,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a suspension of 20.0 g of methyl 4-[4-(phenylacetyl)phenyl]butyrate in 200 ml of methanol, 2.52 g of sodium borohydride was added portionwise under ice-cooling, and stirring was continued for 1 hour. After the reaction solvent was removed under reduced pressure, the residue was added with water and then extracted with ether. After the ether layer was washed with water and dried, the solvent was removed to yield 20.3 g of pale yellow oil.

Aufarbeitung

  1. additionwas added portionwise under ice-
  2. temperaturecooling
  3. customAfter the reaction solvent was removed under reduced pressure
  4. additionthe residue was added with water
  5. extractionextracted with ether
  6. washAfter the ether layer was washed with water
  7. customdried
  8. customthe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-4d93a87cc39344ffbe9de88a23eceed3
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05597848

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