Methanol → Methyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

HRID 2352037

Reaktionsgleichung

Reaktionsgleichung von HRID 2352037
[CH:1]1([C:9]([OH:11])=[O:10])[CH2:5][CH2:4][N:3]2[CH:6]=[CH:7][CH:8]=[C:2]12.[CH3:12]O>Cl>[CH:1]1([C:9]([O:11][CH3:12])=[O:10])[CH2:5][CH2:4][N:3]2[CH:6]=[CH:7][CH:8]=[C:2]12

Komponenten

4

Edukt 2

HCID 887MethanolHCID 127951052,3-Dihydro-1h-pyrrolizine-1-carboxylic acid

Produkt 1

HCID 12795075Methyl 2,3-dihydro-1H-pyrrolizine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid is dissolved in methanol containing a small amount of concentrated hydrochloric acid. The resulting solution is heated to reflux, and then cooled. The title compound is isolated by rotary evaporation of the solvent under reduced pressure, and may be purified by chromatography on silica gel with hexane/ethyl acetate as eluent.

Aufarbeitung

  1. temperatureThe resulting solution is heated
  2. temperatureto reflux
  3. temperaturecooled

Quellen und Nachweise

ORD-Eintrag
ord-586d422b14554575a5537722250183b1
Quelldatensatz
uspto-grants-1989_10
Patentnummer
US04874871

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