Water → 12-Acetyl-5-methoxy-12H-benzo[a]phenothiazine

HRID 2352217Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2352217
[CH3:1]C(C)([O-])C.[K+].[C:7]([N:10]1[C:23]2[C:18](=[CH:19][C:20]([OH:28])=[C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]3=2)[S:17][C:16]2[C:11]1=[CH:12][CH:13]=[CH:14][CH:15]=2)(=[O:9])[CH3:8].CI.O>CN(C=O)C>[C:7]([N:10]1[C:23]2[C:18](=[CH:19][C:20]([O:28][CH3:1])=[C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]3=2)[S:17][C:16]2[C:11]1=[CH:12][CH:13]=[CH:14][CH:15]=2)(=[O:9])[CH3:8]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 1371248512-acetyl-5-hydroxy-12H-benzo[a]phenothiazineHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 1371248612-Acetyl-5-methoxy-12H-benzo[a]phenothiazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Potassium tert-butoxide (800 mg) was added to a solution of 12-acetyl-5-hydroxy-12H-benzo[a]phenothiazine (950 mg) (from Example 3) and methyl iodide (1.5 ml) in DMF (10 ml) and stirred for 15 minutes. Water (80 ml) was added to the reaction mixture and the precipitate was filtered to afford the title compound.

Aufarbeitung

  1. filtrationthe precipitate was filtered

Quellen und Nachweise

ORD-Eintrag
ord-209820e3ab4c49f5abb3a384df8e6aff
Quelldatensatz
uspto-grants-1989_10
Patentnummer
US04876246

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