Triethylamine → 2-(2,5-dioxopyrrolidin-1-yl)ethyl Methanesulfonate

HRID 2353482Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2353482
[OH:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[CH2:7][CH2:6][C:5]1=[O:10].C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C1COCC1>[CH3:18][S:19]([O:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[CH2:7][CH2:6][C:5]1=[O:10])(=[O:21])=[O:20]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 236334N-[2-Hydroxyethyl]succinimide

Produkt 1

HCID 100822242-(2,5-dioxopyrrolidin-1-yl)ethyl Methanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The N-(2-hydroxyethyl)succinimide (Aldrich, 0.19 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Quellen und Nachweise

ORD-Eintrag
ord-377c69ae356f42ff83e7b22408d457a9
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07750039B2

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