Triethylamine → Methanesulfonic acid 2-(1-methyl-pyrrolidin-2-yl)-ethyl ester

HRID 2353486

Reaktionsgleichung

Reaktionsgleichung von HRID 2353486
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][OH:9].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1COCC1>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][O:9][S:18]([CH3:17])(=[O:20])=[O:19]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 933631-Methyl-2-pyrrolidineethanol

Produkt 1

HCID 44627019Methanesulfonic acid 2-(1-methyl-pyrrolidin-2-yl)-ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The 1-methyl-2-pyrrolidineethanol (Aldrich, 0.16 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Quellen und Nachweise

ORD-Eintrag
ord-635bb0d0af864afd91106917bbcf7337
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07750039B2

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