Morpholine → 4-(4-Nitropyridin-2-yl)morpholine

HRID 2353548

Reaktionsgleichung

Reaktionsgleichung von HRID 2353548
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>C1COCC1>[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=1)([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 707344-Nitropyridine

Produkt 1

HCID 574185464-(4-Nitropyridin-2-yl)morpholineAusbeute 56,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue purified by column chromatography (2/1 Hex/EtOAc)

Quellen und Nachweise

ORD-Eintrag
ord-2980c9148a43422cb224823d9fcf9fe8
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07749999B2

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