Isopropyl isocyanate → 3-[4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]-1-propan-2-yl-urea

HRID 2353637Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2353637
[CH3:1][S:2]([CH2:5][C:6]1[CH:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[N:9]=[C:8]([C:18]2[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=2)[N:7]=1)(=[O:4])=[O:3].[CH:25]([N:28]=[C:29]=[O:30])([CH3:27])[CH3:26]>O1CCOCC1>[CH3:1][S:2]([CH2:5][C:6]1[CH:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[N:9]=[C:8]([C:18]2[CH:24]=[CH:23][C:21]([NH:22][C:29](=[O:30])[NH:28][CH:25]([CH3:27])[CH3:26])=[CH:20][CH:19]=2)[N:7]=1)(=[O:4])=[O:3]

Komponenten

4

Edukt 2

HCID 61277Isopropyl isocyanateHCID 593800394-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline

Produkt 1

HCID 248046593-[4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]-1-propan-2-yl-ureaAusbeute 43,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]aniline (70 mg, 0.2 mmol) and isoproylisocyanate (0.1 mL, 1 mmol) were heated in dioxane (2 mL) at 70° C. for 4 hours. The reaction mixture was evaporated and the residue triturated with ethyl acetate. The suspension was filtered and the white solid washed with ethyl acetate and diethyl ether then dried under vacuum at 60° C. overnight to yield the title compound (38 mg).

Aufarbeitung

  1. customThe reaction mixture was evaporated
  2. customthe residue triturated with ethyl acetate
  3. filtrationThe suspension was filtered
  4. washthe white solid washed with ethyl acetate and diethyl ether
  5. customthen dried under vacuum at 60° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-3c09b0b3478244208be315ca3b1b4eb4
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07750003B2

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