Water → Benzphetamine Hydrochloride

HRID 2354145

Reaktionsgleichung

Reaktionsgleichung von HRID 2354145
[CH3:1][C@H:2]([NH:10][CH3:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.[CH2:12]([Cl:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+].O>C1(C)C=CC=CC=1>[CH3:1][C@H:2]([N:10]([CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[CH3:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.[ClH:19]

Komponenten

6

Edukt 4

HCID 962WaterHCID 7503Benzyl ChlorideHCID 10340Sodium CarbonateHCID 10836Methamphetamine

Produkt 1

HCID 11558159Benzphetamine HydrochlorideAusbeute 82,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

Benzphetamine hydrochloride is prepared in typical fashion in toluene. After reaction of methamphetamine with benzyl chloride in the presence of sodium carbonate, the reaction mass contained 28.76 g (0.1202 mole) of the acid salt which was a yield of 82.5%. To the reaction mass were added 100 g of deionized water. The mixture was stirred to dissolve the salts and then transferred to a separatory funnel. The reaction flask was rinsed with 50 g of water and 65 g of toluene. The rinsings were added to the separatory funnel. The layers were separated into a 169.5 g water layer and a 104.2 g of organic layer. The water layer was extracted twice with 27 g portions of toluene. The organic layers were combined bringing the total amount of organic medium to 156.1 g. The combined toluene portions were then washed with 33 g of deionized water.

Aufarbeitung

  1. dissolutionto dissolve the salts
  2. customtransferred to a separatory funnel
  3. washThe reaction flask was rinsed with 50 g of water and 65 g of toluene
  4. additionThe rinsings were added to the separatory funnel
  5. customThe layers were separated into a 169.5 g water layer
  6. extractionThe water layer was extracted twice with 27 g portions of toluene
  7. washThe combined toluene portions were then washed with 33 g of deionized water

Quellen und Nachweise

ORD-Eintrag
ord-dd499fe85542460b9eccf5c91f07096a
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07750187B2

Verknüpfte Notizen

Wird geladen…