Hydrochloric Acid → N-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide hydrochloride

HRID 235431

Reaktionsgleichung

Reaktionsgleichung von HRID 235431
[F:1][C:2]1[CH:29]=[CH:28][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]4[C:21](=[O:22])[C:20]5=[CH:23][CH:24]=[CH:25][CH:26]=[C:19]5[C:18]4=[O:27])[CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1.[ClH:30]>ClCCl.C(O)C.CCOCC>[ClH:30].[F:1][C:2]1[CH:29]=[CH:28][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]4[C:18](=[O:27])[C:19]5=[CH:26][CH:25]=[CH:24][CH:23]=[C:20]5[C:21]4=[O:22])[CH2:11][CH2:10]3)=[N:7][O:8][C:4]=2[CH:3]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 98653575-HT6/7 antagonist 1

Produkt 1

HCID 18467219N-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 21584144Dichloromethane ethanolLösungsmittel

Versuchsvorschrift

To a solution of 8.0 g of N-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]phthalimide in dichloromethane/ethanol (150 ml) was added 1M--HCl in ether. The salt crystallized out rapidly. It was filtered off, washed with ethanol and dried to afford 8.15 g with m.p.=257°-259° C. dec. Recrystallization provided 7.20 g of pure white salt, with m.p. unchanged.

Aufarbeitung

  1. customThe salt crystallized out rapidly
  2. filtrationIt was filtered off
  3. washwashed with ethanol
  4. customdried
  5. customto afford 8.15 g with m.p.=257°-259° C. dec
  6. customRecrystallization

Quellen und Nachweise

ORD-Eintrag
ord-32407b741fbe4c4c945fc5a0bc1c002d
Quelldatensatz
uspto-grants-1997_01
Patentnummer
US05597842

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