Morpholine → N-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-2-morpholin-4-yl-acetamide

HRID 2356934Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2356934
[CH3:1][C:2]1([CH3:32])[C:6](=[O:7])[N:5]([C:8]2[CH:9]=[CH:10][C:11]([O:19][C:20]([F:23])([F:22])[F:21])=[C:12]([NH:14][C:15](=[O:18])[CH2:16]Cl)[CH:13]=2)[C:4](=[O:24])[N:3]1[CH2:25][C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1.[NH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[CH3:1][C:2]1([CH3:32])[C:6](=[O:7])[N:5]([C:8]2[CH:9]=[CH:10][C:11]([O:19][C:20]([F:23])([F:22])[F:21])=[C:12]([NH:14][C:15](=[O:18])[CH2:16][N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)[CH:13]=2)[C:4](=[O:24])[N:3]1[CH2:25][C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1

Komponenten

3

Edukt 2

HCID 8083MorpholineHCID 23110283N-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-2-chloro-acetamide

Produkt 1

HCID 11642143N-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-2-morpholin-4-yl-acetamide

Versuchsvorschrift

50 mg N-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-2-chloro-acetamide (raw material, as described above) owere dissolved in 2 ml morpholine and heated for 1 h to 50° C. Subsequently, the mixture was poured on ice and extracted with ethylacetate. The combined organic phases were evaporated to dryness and the residue was purified by flash chromoatography (Silica gel, methylene chloride:methanol=1.98:22.95:5) Yield: 20 mg

Aufarbeitung

  1. temperatureheated for 1 h to 50° C
  2. additionSubsequently, the mixture was poured on ice
  3. extractionextracted with ethylacetate
  4. customThe combined organic phases were evaporated to dryness
  5. customthe residue was purified by flash chromoatography (Silica gel, methylene chloride:methanol=1.98:22.95:5) Yield: 20 mg

Quellen und Nachweise

ORD-Eintrag
ord-7c4e906c3c6e4cc689578e9045b16fa1
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07759379B2

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