Acryloyl chloride → n-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-acrylamide

HRID 2356938Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2356938
[NH2:1][C:2]1[CH:3]=[C:4]([N:13]2[C:17](=[O:18])[C:16]([CH3:20])([CH3:19])[N:15]([CH2:21][C:22]3[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=3)[C:14]2=[O:28])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].[C:29](Cl)(=[O:32])[CH:30]=[CH2:31]>ClCCCl>[CH3:19][C:16]1([CH3:20])[C:17](=[O:18])[N:13]([C:4]2[CH:5]=[CH:6][C:7]([O:8][C:9]([F:10])([F:11])[F:12])=[C:2]([NH:1][C:29](=[O:32])[CH:30]=[CH2:31])[CH:3]=2)[C:14](=[O:28])[N:15]1[CH2:21][C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1

Komponenten

4

Edukt 2

HCID 13140Acryloyl chlorideHCID 231103083-(3-Amino-4-trifluoromethoxyphenyl)5,5-dimethyl-1-pyridin-4-ylmethylimidazolidine-2,4-dione

Produkt 1

HCID 23110311n-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-acrylamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
-20 °C

Versuchsvorschrift

1000 mg (2.54 mmol) 3-(3-amino-4-trifluormethoxy-phenyl)-5,5-dimethyl-1-pyridin-4-ylmethyl-imidazolidine-2,4-dione were dissolved in 25 ml 1,2-dichloroethane. The mixture was cooled to −20° C. and treated with a solution of 272 mg (3.00 mmol) acrylic acid chloride in 5 ml 1,2-dichloroethane. The mixture was allowed to reach RT, and then evapoarted to dryness. The raw material was used without further purification.

Aufarbeitung

  1. customto reach RT
  2. customThe raw material was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-d25fd5b1f425402fac1fb9b7d0cc1b45
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07759379B2

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