HCID 178518953, Verbindung → aza-THIP

HRID 2357681Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2357681
C([N:8]1[CH2:13][CH2:12][C:11]2[C:14]([OH:17])=[N:15][NH:16][C:10]=2[CH2:9]1)C1C=CC=CC=1>[Pd].CO>[NH:16]1[C:10]2[CH2:9][NH:8][CH2:13][CH2:12][C:11]=2[C:14]([OH:17])=[N:15]1

Komponenten

4

Edukt 1

HCID 178518953HCID 178518953, Verbindung

Produkt 1

HCID 178518952aza-THIP

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 6-benzyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-ol (2.00 g, 8.72 mmol) and palladium on carbon (0.200 g, 1.88 mmol, Aldrich) in MeOH (100 mL) was stirred under H2 atmosphere for 48 h. The mixture was filtered through Celite® and the filter cake was washed with MeOH. The mixture was concentrated in vacuo. The filter cake was washed with water and the filtrate was concentrated in vacuo. Both fractions contained the title compound. MS (ESI, pos. ion) m/z: 140 (M+1).

Aufarbeitung

  1. filtrationThe mixture was filtered through Celite®
  2. washthe filter cake was washed with MeOH
  3. concentrationThe mixture was concentrated in vacuo
  4. washThe filter cake was washed with water
  5. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0a62205f17014cc2b18655f26601f55c
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07759337B2

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