Water → HCID 59304580, Verbindung

HRID 2357877Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2357877
[CH2:1]([C:3]1[C:12]2[C:11](=[O:13])[NH:10][C:9](=[S:14])[NH:8][C:7]=2[O:6][C:5](=[O:15])[CH:4]=1)[CH3:2].O.[CH3:17]N(C=O)C>>[CH2:1]([C:3]1[C:12]2[C:11](=[O:13])[NH:10][C:9]([S:14][CH3:17])=[N:8][C:7]=2[O:6][C:5](=[O:15])[CH:4]=1)[CH3:2]

Komponenten

4

Edukt 3

HCID 962WaterHCID 6228DimethylformamideHCID 533226895-ethyl-2-mercapto-3H-pyrano[2,3-d]pyrimidine-4,7-dione

Produkt 1

HCID 59304580HCID 59304580, VerbindungAusbeute 96 %

Versuchsvorschrift

Mel (2.23 mL, 35.72 mmol) was added to a suspension of 5-ethyl-2-thioxo-2,3-dihydro-1h-pyrano[2,3-d]pyrimidine-4,7-dione (4.0 g, 17.86 mmol) in DMF (40 mL) at room temperature. The reaction mixture was stirred at room temperature overnight. The reaction mixture was then poured into water (250 mL) and filtered through a sintered funnel. The solid residue was washed with water (2×50 mL) and dried under vacuum to give 5-ethyl-2-methylsulfanyl-3H-pyrano[2,3-d]pyrimidine-4,7-dione (4.1 g, 96%).

Aufarbeitung

  1. filtrationfiltered through a sintered funnel
  2. washThe solid residue was washed with water (2×50 mL)
  3. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-97fd655668d64ad5ae02c0b86fa9b5ab
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07763623B2

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