Methanol → 3a-Methyl-6-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-1,2,4,5,9a,9b-hexahydro-3aH-9-oxa-cyclopenta[a]naphthalene-3,7-dione

Temperatur

0 °C

A 25% (w/w) solution of sodium methoxide in methanol (2.71 mL, 12.8 mmol, 1 eq) was added to the stirred solution of 7a-Methyl-4-[5-(2-methyl-[1,3]dioxolan-2-yl)-2-oxo-pentyloxy]-hexahydro-indene-1,5-dione (4.5 g, 12.8 mmol, 1 eq) in toluene (200 mL) at 0° C. The reaction mixture was stirred at 0° C. for 1 h, then the reaction was quenched with a 10:1 (v/v) of ammonium chloride/potassium bisulfate solution (100 mL). The aqueous layer was extracted with ethyl acetate (2×100 mL), and the combined organic layer was dried with magnesium sulfate. The resulting solution was then filtered and concentrated to yield the title compound as an oil, which was used in the next step without further purification.

1. customthe reaction was quenched with a 10:1 (v/v) of ammonium chloride/potassium bisulfate solution (100 mL)
2. extractionThe aqueous layer was extracted with ethyl acetate (2×100 mL)
3. dry with materialthe combined organic layer was dried with magnesium sulfate
4. filtrationThe resulting solution was then filtered
5. concentrationconcentrated

ORD-Eintrag

ord-93cac694a7e04e3b8f88cb9ce2d4fbbb

Quelldatensatz

uspto-grants-2010_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07763648B2