Dimethylformamide → 2-Hydroxy-4-methoxybenzoyl chloride

HRID 2358311

Reaktionsgleichung

Reaktionsgleichung von HRID 2358311
[OH:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:15])=O.CN(C=O)C>ClCCCl>[OH:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:15])=[O:5]

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 752314-Methoxysalicylic Acid

Produkt 1

HCID 231185592-Hydroxy-4-methoxybenzoyl chlorideAusbeute 99,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

To a solution of 2-hydroxy-p-anisic acid (0.2 g, 1.2 mmol) in DCE (8 mL) was added thionyl chloride (0.13 mL, 1.8 mmol) and a drop of DMF. After stirring at room temperature for 4.5 h the reaction mixture was concentrated and azeotroped several times with benzene to give the acid chloride 123 as a white solid (222 mg).

Aufarbeitung

  1. concentrationwas concentrated
  2. customazeotroped several times with benzene

Quellen und Nachweise

ORD-Eintrag
ord-bfaddc38c3fc471697e8ad06e946ba5b
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07763614B2

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