Iodoethane → 2-Butyl-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

HRID 2358573Notizen

Reaktionsgleichung

[CH3:1][C:2]1[N:3]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[CH2:15](I)[CH2:16][CH3:17].C(I)C>>[CH2:14]([C:10]1[CH:11]=[CH:12][CH:13]=[C:8]([N:3]2[C:2]([CH3:1])=[CH:6][CH:5]=[C:4]2[CH3:7])[N:9]=1)[CH2:15][CH2:16][CH3:17]

Komponenten

Edukt 3

HCID 6340Iodoethane

HCID 336431-Iodopropane

HCID 7931562-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-methylpyridine

Produkt 1

HCID 133983052-Butyl-6-(2,5-dimethyl-pyrrol-1-yl)-pyridineAusbeute 64,4 %

Versuchsvorschrift

The product from Example 2a 1.0 g, 5.37 mmol) was reacted with propyl iodide 0.55 mL, 5.64 mmol) in place of ethyl iodide following the procedure from Example 2b to give the title compound (790 mg, 64%).

Quellen und Nachweise

ORD-Eintrag: ord-89d09835880d42a8a45f27d8d01f4814
Quelldatensatz: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07763731B2

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