Diethanolamine → HCID 22590162, Verbindung

HRID 23612

Reaktionsgleichung

Reaktionsgleichung von HRID 23612
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1F)[C:6]#[N:7].[NH:14]([CH2:18][CH2:19][OH:20])[CH2:15][CH2:16][OH:17]>CN(C)C(=O)C>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[N:14]([CH2:18][CH2:19][OH:20])[CH2:15][CH2:16][OH:17])[C:6]#[N:7]

Komponenten

4

Edukt 2

HCID 8113DiethanolamineHCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrile

Produkt 1

HCID 22590162HCID 22590162, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

A solution of 3-trifluoromethyl 4-fluoro-benzonitrile (9.45 g, 50 mmol) and diethanolamine (15.8 g, 0.15 mol) in N,N-dimethylacetamide (200 ml) was stirred for 7 days at 50° C. The solvent was evaporated, the residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml), the organic layer dried (MgSO4) and evaporated to dryness. The residue was chromatographed using CH2Cl2-EtOH as eluent.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml)
  3. dry with materialthe organic layer dried (MgSO4)
  4. customevaporated to dryness
  5. customThe residue was chromatographed

Quellen und Nachweise

ORD-Eintrag
ord-02ab42cfd43b416bbf1faed23df2983f
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06852755B1

Verknüpfte Notizen

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