Acetic Anhydride → HCID 12896718, Verbindung

HRID 2361627Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2361627
[C@@H:1]1([N:10]2[CH:15]=[CH:14][C:13](=[O:16])[NH:12][C:11]2=[O:17])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3].C(O[C:22](=[O:24])[CH3:23])(=O)C>N1C=CC=CC=1>[C:2]([O:3][C@H:2]1[C@H:4]([O:5][C:4](=[O:5])[CH3:6])[C@@H:6]([CH2:8][O:9][C:22](=[O:24])[CH3:23])[O:7][C@H:1]1[N:10]1[CH:15]=[CH:14][C:13](=[O:16])[NH:12][C:11]1=[O:17])(=[O:3])[CH3:1]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 18323Uracil Arabinoside

Produkt 1

HCID 12896718HCID 12896718, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

500 mg (2.05 mmol) of the above product 3 is taken as the starting material, and dissolved in 35 mL of pyridine. Then 11 ml of acetic anhydride is added with continuously stirring. The solution is concentrated under reduced pressure by removing the residual part of the solution after the completion of the reaction, and then purified by rapid column chromatography (acetone/n-hexane=4:5). A white product (1-(2′,3′,5′-Tri-O-acetyl-β-D-arabinofuranosyl)-pyrimidin-2,4-(3H)-dione) 4 is obtained. Its weight and yield are 675 mg and 89% respectively.

Aufarbeitung

  1. concentrationThe solution is concentrated under reduced pressure
  2. customby removing the residual part of the solution
  3. customafter the completion of the reaction
  4. custompurified by rapid column chromatography (acetone/n-hexane=4:5)

Quellen und Nachweise

ORD-Eintrag
ord-19a103e640fc4e2f93ba7714bc8c86ab
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08691789B2

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