Bromine → 2-Bromo-4,4,4-trifluorobutyraldehyde

Temperatur

0 °C

To a mixture of 4,4,4-trifluorobutyraldehyde (5 g, 39.68 mmol) in 1,4-dioxane (5 ml) cooled to 0° C., bromine (2.24 ml, 43.65 mmol) was added dropwise. The reaction mixture was stirred at 0° C. for 2 h. The resulting reaction mixture was filtered through a pad of diatomaceous earth and the filtrate was washed with NaHCO3 (aqueous sat. solution). The organic layer was separated, dried (MgSO4) and evaporated in vacuo to yield compound D4 (6.2 g, 76%) that was used in the next reaction step without further purification.

1. customThe resulting reaction mixture
2. filtrationwas filtered through a pad of diatomaceous earth
3. washthe filtrate was washed with NaHCO3 (aqueous sat. solution)
4. customThe organic layer was separated
5. dry with materialdried (MgSO4)
6. customevaporated in vacuo

ORD-Eintrag

ord-b900e6d946eb4e79b7397e274629fbd3

Quelldatensatz

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08691813B2