Ammonium Hydroxide → 5-Amino-2-thiophenecarboxamide

Reaktionsgleichung

C[O:2][C:3]([C:5]1[S:6][C:7]([NH2:10])=[CH:8][CH:9]=1)=O.[NH4+:11].[OH-]>>[NH2:10][C:7]1[S:6][C:5]([C:3]([NH2:11])=[O:2])=[CH:9][CH:8]=1

Komponenten

Edukt 2

HCID 14923Ammonium Hydroxide

HCID 7131725Methyl 5-amino-2-thiophenecarboxylate

Produkt 1

HCID 450841625-Amino-2-thiophenecarboxamideAusbeute 47,4 %

Reaktionsbedingungen

Temperatur: 60 °C

Versuchsvorschrift

A 18 ml vial was loaded with 5-amino-thiophene-2-carboxylic acid methylester (250 mg, 1.59 mmole) and 5 ml of 30% NH4OH. The vial was sealed and the mixture was heated at 60° C. for 24 hours. The mixture was cooled down and concentrated to give 200 mg crude product, 47.4% yield.

Aufarbeitung

customThe vial was sealed
temperatureThe mixture was cooled down
concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag: ord-b42d4bcdf5fd4421a3d8a0ce646d6f1f
Quelldatensatz: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08691816B2

Notizen zur Reaktion

Wird geladen…