Ethanol → Dazoquinast

HRID 236319Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 236319
[OH-].[Na+].[CH:3]1[N:7]2[C:8]3[C:13]([N:14]=[CH:15][C:6]2=[N:5][C:4]=1[C:16]([O:18]CC)=[O:17])=[CH:12][CH:11]=[CH:10][CH:9]=3.C(O)C>O>[CH:3]1[N:7]2[C:8]3[C:13]([N:14]=[CH:15][C:6]2=[N:5][C:4]=1[C:16]([OH:18])=[O:17])=[CH:12][CH:11]=[CH:10][CH:9]=3

Komponenten

5

Edukt 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 13228325Ethyl imidazo[1,2-a]quinoxaline-2-carboxylate

Produkt 1

HCID 71146DazoquinastAusbeute 107,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

10 ml of 1N sodium hydroxide solution were added to a suspension of 0.63 g of ethyl imidazo-[1,2-a]-quinoxaline-2-carboxylate, 10 ml of ethanol and 30 ml of water and the mixture was refluxed for one hour. The ethanol was evaporated under reduced pressure from the resulting clear yellow solution and the aqueous phase was acidified with concentrated hydrochloric acid. The mixture was filtered to obtain 0.6 g of imidazo-[1,2-a]-quinoxaline-2-carboxylic acid in the form of a buff crystalline solid melting at 274°-275° C.

Aufarbeitung

  1. temperaturethe mixture was refluxed for one hour
  2. customThe ethanol was evaporated under reduced pressure from the resulting clear yellow solution
  3. filtrationThe mixture was filtered

Quellen und Nachweise

ORD-Eintrag
ord-e13a3de72d294beabe5c5d2727d101b0
Quelldatensatz
uspto-grants-1987_02
Patentnummer
US04644002

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