(Piperidine-1-yl)-acetic acid-benzylester → Piperidin-1-yl-acetic acid

HRID 2364932Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2364932
C([O:8][C:9](=[O:17])[CH2:10][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[N:11]1([CH2:10][C:9]([OH:17])=[O:8])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Komponenten

4

Edukt 1

HCID 11379293(Piperidine-1-yl)-acetic acid-benzylester

Produkt 1

HCID 201097Piperidin-1-yl-acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

10.4 g (44 mMol) (piperidine-1-yl)-acetic acid-benzylester 9 was stirred with 0.25 g Pd/C (5%) in 100 ml Methanol at RT. Under normal pressure, the reaction mixture was reduced (hydrated) with H2. After having removed the catalyst, the solution was evaporated and the residue was resuspended in EtOAc and filtered off.

Aufarbeitung

  1. customAfter having removed the catalyst
  2. customthe solution was evaporated
  3. filtrationfiltered off

Quellen und Nachweise

ORD-Eintrag
ord-3c06d4dd3ff941a0b0af65238a7c5a8d
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08697604B2

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