Water → [1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-3-yl]methanol

To a suspension of LiAlH4 (0.11 g, 2.78 mmol) in dry THF (1 ml) was added 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidine-3-carboxylic acid ethyl ester (0.17 g, 0.55 mmol) in dry THF (10 ml). The reaction mixture was refluxed for 2 h. Water was slowly added under cooling and the reaction mixture was extracted with EtOAc (3×20 ml). The combined organic phases were dried (Na2SO4), filtered and the filtrate was evaporated to give the title compound.

1. temperatureThe reaction mixture was refluxed for 2 h
2. temperatureunder cooling
3. extractionthe reaction mixture was extracted with EtOAc (3×20 ml)
4. dry with materialThe combined organic phases were dried (Na2SO4)
5. filtrationfiltered
6. customthe filtrate was evaporated

ORD-Eintrag

ord-43ef67ccb6644fd3a3e9de4147fc4485

Quelldatensatz

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08697723B2