Hydrochloric Acid → Methyl 2-amino-5-chlorobenzoate

HRID 236620

Reaktionsgleichung

Reaktionsgleichung von HRID 236620
[ClH:1].[NH2:2][C:3]1[CH:11]=[C:10](Cl)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[C:13](=O)([O-])[O-].[Na+].[Na+]>CO.O>[NH2:2][C:3]1[CH:11]=[CH:10][C:9]([Cl:1])=[CH:8][C:4]=1[C:5]([O:7][CH3:13])=[O:6]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 666462-Amino-4-chlorobenzoic acid

Produkt 1

HCID 78878Methyl 2-amino-5-chlorobenzoateAusbeute 57,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of hydrogen chloride (27.1 g) in methanol (192.2 g) is stirred at room temperature and 2-amino-4-chlorobenzoic acid (25 g) is added. The mixture is heated under reflux for 10 hours, then cooled and neutralised with a solution of sodium carbonate (20 g) in water (200 ml). The solid is filtered off, washed with water, and dried in vacuo at 65° C. to give methyl 2-amino-5-chlorobenzoate (15.5 g).

Aufarbeitung

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 10 hours
  3. temperaturecooled
  4. filtrationThe solid is filtered off
  5. washwashed with water
  6. customdried in vacuo at 65° C.

Quellen und Nachweise

ORD-Eintrag
ord-feef69200ce947deb4605e8d75cc6675
Quelldatensatz
uspto-grants-1987_02
Patentnummer
US04645818

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