Water → HCID 178512607, Verbindung

HRID 236647

Reaktionsgleichung

Reaktionsgleichung von HRID 236647
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[C:6](=O)[CH2:7]Br)([O-:3])=[O:2].[C:14]([NH:17][C:18]([NH2:20])=[S:19])(=[NH:16])[NH2:15].O.[OH-].[Na+]>CN(C)C=O>[NH:17]([C:18]1[S:19][CH:7]=[C:6]([C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[N+:1]([O-:3])=[O:2])[N:20]=1)[C:14]([NH2:16])=[NH:15]

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 2440252-Bromo-2'-nitroacetophenoneHCID 178513045HCID 178513045, Verbindung

Produkt 1

HCID 178512607HCID 178512607, VerbindungAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 16.5 gm of 2-nitro-phenacyl bromide and 7.98 gm of amidinothiourea in 70 ml of dimethylformamide was stirred at room temperature for 16 hours, and then poured into 350 ml of water. The solution was made alkaline with 10% sodium hydroxide, and the solid which separated out after cooling was filtered, washed with water and dried, yielding 16.9 gm of the title compound, m.p. 176°-178° C.

Aufarbeitung

  1. customthe solid which separated out
  2. temperatureafter cooling
  3. filtrationwas filtered
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0999f81bbcdc4f8fac59951338ee04e7
Quelldatensatz
uspto-grants-1987_02
Patentnummer
US04645841

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