HCID 68420297, Verbindung → 1-Piperidin-4-yl-dihydropyrimidin-2,4(1H,3H)-dione

HRID 2366555Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2366555
[O:1]=[C:2]1[NH:7][C:6](=[O:8])[CH2:5][CH2:4][N:3]1[CH:9]1[CH2:14][CH2:13][N:12](C(OCC2C=CC=CC=2)=O)[CH2:11][CH2:10]1>[Pd].CN(C=O)C>[NH:12]1[CH2:11][CH2:10][CH:9]([N:3]2[CH2:4][CH2:5][C:6](=[O:8])[NH:7][C:2]2=[O:1])[CH2:14][CH2:13]1

Komponenten

4

Edukt 1

HCID 68420297HCID 68420297, Verbindung

Produkt 1

HCID 134241411-Piperidin-4-yl-dihydropyrimidin-2,4(1H,3H)-dioneAusbeute 102,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of benzyl 4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)piperidin-1-carboxylate (0.18 g) obtained in Example 45d) and 20% palladium on carbon (containing 60% water, 36 mg) in DMF (10 mL) was stirred at room temperature for 3 hours under a hydrogen atmosphere, and the catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to obtain the title compound (0.11 g, quantitative) as a white powder.

Aufarbeitung

  1. customthe catalyst was removed by filtration
  2. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c812bab776f94b558755c05f49d0596d
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08697865B2

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