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Dimethylformamide → 2-[1-(4-amino-3-nitrophenyl)ethenyl]-N-[3-(trifluoromethyl)phenyl]benzamide

HRID 2367118
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2367118
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:28]=[CH:27][CH:26]=[CH:25][C:11]=2[C:12]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)=[O:13])=[CH2:9])=[CH:4][C:3]=1[N+:29]([O-:31])=[O:30].[N-:32]=[N+]=[N-].[Na+].CN(C)C=O.[BH4-].[Na+]>C(OCC)(=O)C.O1CCCC1>[NH2:32][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:28]=[CH:27][CH:26]=[CH:25][C:11]=2[C:12]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)=[O:13])=[CH2:9])=[CH:4][C:3]=1[N+:29]([O-:31])=[O:30]
KomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

7

Edukt 4

HCID 6228DimethylformamideHCID 33557Sodium AzideHCID 4311764Sodium borohydrideHCID 67045429HCID 67045429, Verbindung

Produkt 1

HCID 670444852-[1-(4-amino-3-nitrophenyl)ethenyl]-N-[3-(trifluoromethyl)phenyl]benzamideAusbeute 50 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028
Tetrahydrofuran
Lösungsmittel
HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 2-[1-(4-chloro-3-nitrophenyl)ethenyl]-N-[3-(trifluoromethyl)phenyl]benzamide (0.72 g, 1.6 mmol), sodium azide (3.1 g, 4.8 mmol) and N,N-dimethylformamide (2 mL) was stirred 60° C. for 18 hours. The reaction mixture was diluted with ethyl acetate (50 mL), washed with water (3×30 mL), brine (30 mL), dried over sodium sulfate, filtered and concentrated to give an oily residue. This residue was dissolved in tetrahydrofuran, cooled to 0° C. then sodium borohydride (0.11 g, 2.7 mmol) was added and stirring was continued for 30 minutes at room temperature. The reaction mixture was quenched with methanol (2 mL), concentrated then diluted with ethyl acetate (50 mL). The organic solution was washed with water (30 mL) then brine solution (30 mL) then dried over sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography (silica gel, eluting with 15-50% ethyl acetate-hexane) to give 2-[1-(4-amino-3-nitrophenyl)ethenyl]-N-[3-(trifluoromethyl)phenyl]benzamide (0.35 g, 0.8 mmol, 50% yield). MS (EI) for C22H16F3N3O3: 428 (MH+).

Aufarbeitung

  1. washwashed with water (3×30 mL), brine (30 mL)
  2. dry with materialdried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customto give an oily residue
  6. temperaturecooled to 0° C.
  7. stirringstirring
  8. waitwas continued for 30 minutes at room temperature
  9. customThe reaction mixture was quenched with methanol (2 mL)
  10. concentrationconcentrated
  11. additionthen diluted with ethyl acetate (50 mL)
  12. washThe organic solution was washed with water (30 mL)
  13. dry with materialbrine solution (30 mL) then dried over sodium sulfate
  14. filtrationfiltered
  15. concentrationconcentrated
  16. customThe residue was purified by flash chromatography (silica gel, eluting with 15-50% ethyl acetate-hexane)

Quellen und Nachweise

ORD-Eintrag
ord-283cfd33120045df85d726cfe31b4811
Quelldatensatz
uspto-grants-2014_04
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08697737B2

Notizen zur Reaktion

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