Hydrochloric Acid → 2-(2-Morpholinyl)-4,5,6,7-tetrahydro-1H-benzimidazole

HRID 2367344Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2367344
C1(C[N:8]2[CH2:13][CH2:12][O:11][CH:10]([C:14]3[NH:18][C:17]4[CH2:19][CH2:20][CH2:21][CH2:22][C:16]=4[N:15]=3)[CH2:9]2)C=CC=CC=1.Cl>C(O)C.[Pd]>[NH:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]2[NH:15][C:16]3[CH2:22][CH2:21][CH2:20][CH2:19][C:17]=3[N:18]=2)[CH2:9]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 585048062-[4-(Phenylmethyl)-2-morpholinyl]-4,5,6,7-tetrahydro-1H-benzimidazole

Produkt 1

HCID 585044142-(2-Morpholinyl)-4,5,6,7-tetrahydro-1H-benzimidazoleAusbeute 147,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

2-[4-(Phenylmethyl)-2-morpholinyl]-4,5,6,7-tetrahydro-1H-benzimidazole (0.78 g, 2.62 mmol) was hydrogenated in ethanol (30 mL) in the presence of Pd/C (10 wt %, 0.279 g, 0.262 mmol). To the reaction mixture was added 0.2 mL of concentrated hydrochloric acid. After stirring at room temperature overnight, the catalyst was filtered off. The filtrate was concentrated to afford the title compound (0.8 g) as a yellow oil. LC-MS (ES) m/z=208 [M+H]+.

Aufarbeitung

  1. filtrationthe catalyst was filtered off
  2. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-49179edbbc5e499aaebf2cf1e331f81e
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08697685B2

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