Hydrazine → HCID 178446160, Verbindung

HRID 2368582Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2368582
[CH:1]1([C:5]2[NH:13][C:12]3[C:11](=[O:14])[NH:10][C:9](=S)[N:8]([CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:7]=3[N:6]=2)[CH2:4][CH2:3][CH2:2]1.[NH2:21][NH2:22]>O>[CH:1]1([C:5]2[NH:13][C:12]3[C:11](=[O:14])[NH:10]/[C:9](=[N:21]\[NH2:22])/[N:8]([CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:7]=3[N:6]=2)[CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 576002418-cyclobutyl-3-pentyl-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one

Produkt 1

HCID 178446160HCID 178446160, VerbindungAusbeute 38,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

The mixture of 8-cyclobutyl-3-pentyl-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one (0.6 g, 2.0 mmol) in 20 M of hydrazine in water (20 mL) was stirred at 100° C. overnight. After cooling to room temperature, the solid formed was filtered and dried Cooled down, the solid was isolated to give yield the desired product (230 mg, 38.6%). LCMS calculated for C14H23N6O (M+H): 291.2. Found: 291.2.

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. customthe solid formed
  3. filtrationwas filtered
  4. customdried
  5. temperatureCooled down
  6. customthe solid was isolated
  7. customto give

Quellen und Nachweise

ORD-Eintrag
ord-3a6646649f6b495babc0f16ac5e4621c
Quelldatensatz
uspto-grants-2014_04
Patentnummer
US08703783B2

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