Phenylacetyl chloride → HCID 5324449, Verbindung

HRID 236896

Reaktionsgleichung

Reaktionsgleichung von HRID 236896
[CH3:1][C:2]1[S:6][C:5]([NH:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:4][N:3]=1.[C:15]1([CH2:21][C:22](Cl)=[O:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>N1C=CC=CC=1>[C:9]1([CH2:8][N:7]([C:5]2[S:6][C:2]([CH3:1])=[N:3][N:4]=2)[C:22](=[O:23])[CH2:21][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 7679Phenylacetyl chlorideHCID 6460923N-benzyl-5-methyl-1,3,4-thiadiazol-2-amine

Produkt 1

HCID 5324449HCID 5324449, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

N-(5-Methyl-1,3,4-thiadiazol-2-yl)-benzylamine (15 g, 0.073 mole) in pyridine (200 ml) was refluxed with phenylacetyl chloride for 6 hours. The pyridine was removed under educed pressure and the residue treated with water and extracted with ether. The ethereal solution was dried, filtered and evaporated to dryness and the residue recrystallised from ethanol to give the title compound, m.p. 128° C.

Aufarbeitung

  1. customThe pyridine was removed
  2. additionthe residue treated with water
  3. extractionextracted with ether
  4. customThe ethereal solution was dried
  5. filtrationfiltered
  6. customevaporated to dryness
  7. customthe residue recrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-db2c07feefb048ee9746aa08d6125d3f
Quelldatensatz
uspto-grants-1979_06
Patentnummer
US04158659

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