[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:19]([F:22])([F:21])[F:20])[N:11]=[C:10](C(OC)=O)[CH:9]=2)=[CH:4][CH:3]=1.[CH3:27][Mg]Br.CC[O:32][CH2:33][CH3:34]>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:19]([F:21])([F:20])[F:22])[N:11]=[C:10]([C:33]([OH:32])([CH3:34])[CH3:27])[CH:9]=2)=[CH:4][CH:3]=1To a suspension of methyl 5-(4-bromophenyl)-1-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate (393 mg, 0.9 mmol) in dry toluene (9 mL) stirred at ambient temperature was added methylmagnesium bromide (1.4 mL of a 3.0M solution in ether, 4.2 mmol) dropwise. After 2¼ hours stirring at ambient temperature the reaction mixture was quenched by the addition of saturated ammonium chloride and EtOAc. The aqueous layer was extracted with EtOAc (3×). The combined organic extract were dried over Na2SO4, filtered and concentrated under reduced pressure to afford 2-(5-(4-bromophenyl)-1-(2-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)propan-2-ol as an orange-yellow oil, which was carried on to the subsequent step. GC/MS (EI, =426 [M+]
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