Majantol → 2,2-Dimethyl-3-(3-methylcyclohexyl)propan-1-ol

Temperatur

60 °C

5% Rh/C (450 mg, 15% w/w) was charged into a 50 mL autoclave vessel containing a mixture of 2,2-dimethyl-3-(3-methylphenyl)propan-1-ol (6 g, 34 mmol) in water (17 mL). The mixture was vigorously stirred under an hydrogen atmosphere (10 Bar) at 60° C. for 6 h. The reaction mixture was filtered and the filtrate was extracted with MTBE (25 mL), dried over magnesium sulphate and concentrated. The resulting crude product was distilled with a bulb-to-bulb distillation (2.5 mBar, 90° C.) to give 2,2-dimethyl-3-(3-methylcyclohexyl)propan-1-ol (5.1 g, gc purity>99%; yield 82%).

1. additioncontaining
2. filtrationThe reaction mixture was filtered
3. extractionthe filtrate was extracted with MTBE (25 mL)
4. dry with materialdried over magnesium sulphate
5. concentrationconcentrated
6. distillationThe resulting crude product was distilled with a bulb-to-bulb distillation (2.5 mBar, 90° C.)

ORD-Eintrag

ord-beb4fec26d5f494e9bee0fa0dfd974a8

Quelldatensatz

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08709994B2