Potassium Carbonate → HCID 86670028, Verbindung

HRID 2370659

Reaktionsgleichung

[F:1][CH:2](F)[CH2:3]I.[CH3:6][C:7]1([CH3:18])[C:16]2[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=2)[CH2:10][NH:9][CH2:8]1.BrCCF.C([O-])([O-])=O.[K+].[K+]>>[F:1][CH2:2][CH2:3][N:9]1[CH2:8][C:7]([CH3:6])([CH3:18])[C:16]2[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=2)[CH2:10]1

Komponenten

Edukt 4

HCID 11430Potassium Carbonate

HCID 129822-Fluoroethyl bromide

HCID 38335651,1-Difluoro-2-iodoethane

HCID 590215334,4-Dimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine

Produkt 1

HCID 86670028HCID 86670028, Verbindung

Versuchsvorschrift

The title compound was prepared as described in Example 224B, substituting Example 224A and 1,1-difluoro-2-iodoethane with 4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine and 1-bromo-2-fluoroethane, respectively, and using 2.5 equivalent of K2CO3.

Quellen und Nachweise

ORD-Eintrag: ord-3739f900508f44468c459c910bdbdc5d
Quelldatensatz: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08710065B2

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