Methylamine → 3-(2-Chloro-4-fluorophenoxy)-N-methyl-1-azetidinecarboxamide

HRID 2371747

Reaktionsgleichung

Reaktionsgleichung von HRID 2371747
[Cl:1][C:2]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9](Cl)=[O:10])[CH2:6]1.[CH3:17][NH2:18]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]([NH:18][CH3:17])=[O:10])[CH2:6]1

Komponenten

5

Edukt 2

HCID 6329MethylamineHCID 150422343-(2-Chloro-4-fluorophenoxy)-1-azetidinecarbonyl chloride

Produkt 1

HCID 150422183-(2-Chloro-4-fluorophenoxy)-N-methyl-1-azetidinecarboxamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A stirred solution of 2.9 g (0.011 mole) of 3-(2-chloro-4-fluorophenoxy)-1-azetidinecarbonyl chloride in 20 mL of tetrahydrofuran was treated with 4 mL (0.05 mole) of 40% aqueous monomethylamine and stirred for 16 hr. The reaction mixture was diluted with 200 mL of water. The solid which precipitated was collected by filtration (2.7 g). The crude product was recrystallized from benzene/ligroin yielding 2.4 g (84.3%) of fine white crystals, mp 139°-141° C.

Aufarbeitung

  1. customThe solid which precipitated
  2. filtrationwas collected by filtration (2.7 g)
  3. customThe crude product was recrystallized from benzene/ligroin yielding 2.4 g (84.3%) of fine white crystals, mp 139°-141° C.

Quellen und Nachweise

ORD-Eintrag
ord-b829f53ccb3b417f8b09860b96f2687d
Quelldatensatz
uspto-grants-1992_03
Patentnummer
US05095014

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