Acetic Anhydride → HCID 19905480, Verbindung

Reaktionsgleichung

C(N(CC)CC)C.[CH3:8][C:9]1[N:10]([C:15]2[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23]([N:25]([OH:27])[CH3:26])=[O:24])=[CH:17][CH:16]=2)[C:11]([CH3:14])=[CH:12][CH:13]=1.[C:28](OC(=O)C)(=[O:30])[CH3:29]>C(Cl)Cl>[CH3:8][C:9]1[N:10]([C:15]2[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23]([N:25]([O:27][C:28](=[O:30])[CH3:29])[CH3:26])=[O:24])=[CH:17][CH:16]=2)[C:11]([CH3:14])=[CH:12][CH:13]=1

Komponenten

Versuchsvorschrift

Triethylamine (2.06 g) is added to a mixture of 5.0 g of (E)-3-[4-(2,5-dimethyl-1H-pyrrol-1-yl)-phenyl]-N-hydroxy-N-methyl-2-propenamide in 100 ml of methylene chloride and the mixture is stirred for 15 minutes. Acetic anhydride (2.07 g) is added and the mixture is stirred at room temperature overnight. The reaction mixture is washed with water and sodium bicarbonate solution, the organic layer is separated, treated with charcoal, dried and evaporated to dryness. The residue is crystallized from ethanol, water (1:1) to yield (E)-3-[4-(2,5-dimethyl-1H-pyrrol-1-yl)-phenyl]-N-acetoxy-N-methyl-2-propenamide, m.p. 120°-121°.