Sodium Acetate → HCID 85114049, Verbindung

HRID 2372376Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2372376
[CH3:1][CH:2]1[CH2:6][NH:5][C:4](=[S:7])[CH:3]1[C:8]([O:10][CH:11]([CH3:13])[CH3:12])=[O:9].C([O-])(=O)C.[Na+].[CH2:19]([O:21][C:22](=[O:28])[CH2:23][C:24]([CH2:26]Br)=O)[CH3:20]>C(O)C>[CH:11]([O:10][C:8]([C:3]1[CH:2]([CH3:1])[CH2:6][N:5]2[C:24](=[CH:23][C:22]([O:21][CH2:19][CH3:20])=[O:28])[CH2:26][S:7][C:4]=12)=[O:9])([CH3:13])[CH3:12]

Komponenten

5

Edukt 3

HCID 517045Sodium AcetateHCID 575284Ethyl 4-bromo-3-oxobutanoateHCID 10465433Isopropyl 4-Methyl-2-thioxopyrrolidine-3-carboxylate

Produkt 1

HCID 85114049HCID 85114049, VerbindungAusbeute 43,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

4.9 g of isopropyl 4-methyl-2-thioxopyrrolidine-3-carboxylate was dissolved in 50 ml of ethanol and 3.0 g of anhydrous sodium acetate and 7.7 g of 4-bromoacetoacetic acid ethyl ester were added thereto. The obtained mixture was stirred at room temperature for 3.5 hours. The crystals thus precipitated were collected by filtration, washed with water and dried. After recrystallization from a mixture of chloroform and ethanol, 3.3 g of the title compound was obtained.

Aufarbeitung

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customdried
  5. customAfter recrystallization
  6. additionfrom a mixture of chloroform and ethanol

Quellen und Nachweise

ORD-Eintrag
ord-4c9c4bb3448c45f98ce1ec299dad1ffc
Quelldatensatz
uspto-grants-1992_03
Patentnummer
US05098919

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